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\u5e79\u7d30\u80de\u7642\u6cd5\u662f\u76ee\u524d\u5177\u524d\u77bb\u6027\u7684\u518d\u751f\u91ab\u5b78\uff0c\u5982\u524d\u6240\u8ff0\uff0c\u5e79\u7d30\u80de\u662f\u4e00\u7fa4\u53ef\u4ee5\u5206\u5316\u70ba\u8a31\u591a\u4e0d\u540c\u7684\u7279\u5b9a\u7d44\u7e54\u7d30\u80de\u7684\u539f\u59cb\u7d30\u80de\uff0c\u5177\u6709\u767c\u80b2\u6210\u8eab\u9ad4\u5404\u90e8\u4f4d\u7d44\u7e54\u7d30\u80de\u7684\u80fd\u529b\uff0c\u5305\u62ec\u8166\u7d30\u80de\u3001\u5fc3\u81df\u7d30\u80de\u3001\u808c\u8089\u7d30\u80de\u3001\u76ae\u819a\u7d30\u80de\u7b49\u7b49\u3002\u81e8\u5e8a\u4e0a\u5e38\u88ab\u4f7f\u7528\u7684\u5e79\u7d30\u80de\u6709\u56db\u7a2e\uff0c\u5305\u542b\u5e7c\u80ce\u5e79\u7d30\u80de\u3001\u9593\u8cea\u5e79\u7d30\u80de\u3001\u81cd\u5e36\u8840\u5e79\u7d30\u80de\u3001\u8a98\u5c0e\u7684\u591a\u6f5b\u80fd\u6027\u5e79\u7d30\u80de\u3002<\/p>\n\n\n\n

\u5176\u4e2d\uff0c\u9593\u8cea\u5e79\u7d30\u80de\u56e0\u5177\u6709\u591a\u9805\u5206\u5316\u7684\u6f5b\u80fd\uff0c\u53ef\u4f5c\u70ba\u7406\u60f3\u7684\u7a2e\u5b50\u7d30\u80de\uff0c\u5728\u9ad4\u5167\u6216\u9ad4\u5916\u7279\u5b9a\u7684\u8a98\u5c0e\u689d\u4ef6\u4e0b\uff0c\u4e0d\u50c5\u80fd\u5206\u5316\u70ba\u9020\u8840\u5e79\u7d30\u80de\uff0c\u9084\u53ef\u4ee5\u5206\u5316\u70ba\u8102\u80aa\u3001\u786c\u9aa8\u3001\u8edf\u9aa8\u3001\u808c\u8089\u3001\u808c\u8171\u3001\u97cc\u5e36\u3001\u795e\u7d93\u7cfb\u7d71\u7d30\u80de\u3001\u809d\u81df\u3001\u5fc3\u81df\u3001\u8840\u7ba1\u3001\u5167\u76ae\u3001\u80f0\u81df\u7684\u03b2\u7d30\u80de\u4ee5\u53ca\u814e\u81df\u7b49\u591a\u7a2e\u7d44\u7e54\u7d30\u80de\u7684\u80fd\u529b\uff0c\u6539\u5584\u76ee\u524d\u675f\u624b\u7121\u7b56\u7684\u91cd\u5927\u75be\u75c5\u4e4b\u6cbb\u7642\uff0c\u5982\u810a\u9ad3\u640d\u50b7\u3001\u809d\u786c\u5316\u3001\u4e2d\u98a8\u3001\u8001\u5e74\u7661\u5446\u3001\u5e15\u91d1\u68ee\u6c0f\u75c7\uff0c\u4ee5\u53ca\u975e\u5e38\u60e1\u6027\u816b\u7624\u5982\u8166\u8207\u814e\u81df\u816b\u7624\u7b49\u3002<\/p>\n\n\n\n

\u65e5\u672c\u7684\u518d\u751f\u91ab\u5b78\u4e00\u76f4\u9818\u5148\u5168\u7403\uff0c\u5728\u6b64\u57fa\u790e\u4e4b\u4e0b\uff0c\u4eac\u90fd\u5927\u5b78\u79d1\u5b78\u5bb6\u5c71\u4e2d\u4f38\u5f4c\u6559\u6388\u5c07\u56db\u500b\u8f49\u9304\u56e0\u5b50(Oct4\u3001Sox2\u3001c-Myc\u3001Klf4)\u50b3\u9001\u5230\u9ad4\u7d30\u80de\u5167\uff0c\u8a98\u5c0e\u6210\u5e74\u9ad4\u7d30\u80de\u56de\u5230\u5e79\u7d30\u80de\uff0c\u7a31\u70ba\u8a98\u5c0e\u7684\u591a\u6f5b\u80fd\u6027\u5e79\u7d30\u80de(Induced pluripotent stem cell ; iPS)\uff0c\u8b93\u518d\u751f\u91ab\u7642\u6709\u98db\u8e8d\u6027\u7684\u7a81\u7834\u3002<\/p>\n\n\n\n

\u6797\u677e\u6d32\u6307\u51fa\uff0c\u8a98\u5c0e\u591a\u6f5b\u80fd\u6027\u5e79\u7d30\u80deiPS\u4e0d\u53d7\u9ad4\u7d30\u80de\u985e\u578b\u7684\u9650\u5236\uff0c\u53ef\u5229\u7528\u6210\u4eba\u76ae\u819a\u7d30\u80de\u8f49\u63db\u6210iPS\u7d30\u80de\uff0c\u4e0d\u6703\u88ab\u8eab\u9ad4\u6392\u65a5\uff0c\u4e26\u4e14\u53ef\u4ee5\u767c\u80b2\u6210\u591a\u7a2e\u7d44\u7e54\u5668\u5b98\u7684\u80fd\u529b\uff0c\u4f46\u662f\u5b58\u5728\u8457\u764c\u5316\u3001\u816b\u7624\u5316\u7684\u98a8\u96aa\u3002<\/p>\n\n\n\n

\u5c31\u76ee\u524d\u6700\u65b0\u7814\u7a76\u767c\u73fe\uff0cMuse\u7d30\u80de(Multi-lineage differentiating stress enduring cell)\u53ef\u80fd\u6bd4\u539f\u6709\u7684iPS\u7d30\u80de\u66f4\u5f37\u5927\uff0c\u6216\u8a31\u5c07\u80fd\u53d6\u4ee3iPS\u7d30\u80de\u6210\u70ba\u518d\u751f\u91ab\u7642\u7684\u65b0\u738b\u8005\uff01<\/p>\n\n\n\n

Muse\u7d30\u80de \u964d\u4f4e\u4eba\u9ad4\u514d\u75ab\u6392\u65a5\u53cd\u61c9<\/span><\/strong><\/p>\n\n\n\n

Muse\u7d30\u80de\u662f\u5c6c\u65bc\u5167\u6e90\u6027(\u610f\u6307\u9ad4\u5167\u672c\u4f86\u5c31\u5b58\u5728)\u7684\u591a\u529f\u80fd\u4fee\u8b77\u5e79\u7d30\u80de\uff0c\u56e0\u5176\u4e0d\u6613\u764c\u5316\u53ca\u4eba\u9ad4\u6240\u751f\u7684\u5167\u6e90\u6027\u7684\u7279\u6b8a\u6027\uff0c\u5982\u679c\u7d93\u81e8\u5e8a\u8a66\u9a57\u53ef\u4fee\u5fa9\u591a\u7a2e\u5668\u5b98\uff0c\u53ef\u80fd\u5f71\u97ff\u5e79\u7d30\u80de\u7642\u6cd5\u67b6\u69cb\u3002<\/p>\n\n\n\n

\u6797\u677e\u6d32\u8aaa\uff0c\u4eba\u9ad4\u5e7e\u4e4e\u6240\u6709\u4e0d\u540c\u5668\u5b98\u4f86\u6e90\u7684\u7de0\u7d50\u7d44\u7e54\u90fd\u6709Muse\u7d30\u80de\uff0c\u901a\u5e38Muse\u7d30\u80de\u53ef\u5f9e\u5546\u696d\u5316\u7684\u9593\u5145\u8cea\u7d30\u80de\u4e2d\u5206\u96e2\u5f97\u5230\uff0c\u5982\u4eba\u6210\u7e96\u7dad\u7d30\u80de\u3001\u9aa8\u9ad3\u9593\u5145\u8cea<\/p>\n\n\n\n

\u5e79\u7d30\u80de\u53ca\u8102\u80aa\u5e79\u7d30\u80de\u90fd\u53ef\u62bd\u96e2\u51faMuse\u7d30\u80de\u3002<\/p>\n\n\n\n

Muse\u672c\u8eab\u4e0d\u6613\u764c\u5316\u3001\u5bb9\u6613\u53d6\u5f97\u53ca\u5167\u6e90\u6027\u7684\u591a\u91cd\u7279\u9ede\uff0c\u53ef\u61c9\u7528\u65bc\u4fee\u5fa9\u591a\u7a2e\u4e0d\u540c\u75be\u75c5\u3002\u5728\u81e8\u5e8a\u65bd\u4f5c\u4e0a\uff0c\u8207\u5e79\u7d30\u80de\u985e\u4f3c\uff0c\u53ea\u9700\u975c\u8108\u6ce8\u5c04\uff0cMuse\u7d30\u80de\u5c31\u6703\u81ea\u884c\u96a8\u8840\u6db2\u5faa\u74b0\u81ea\u52d5\u6b78\u5de2\u9054\u5230\u8eab\u9ad4\u53d7\u640d\u7684\u5668\u5b98\u6216\u7d44\u7e54\u4f4d\u7f6e\uff0c\u9032\u884c\u4e0d\u540c\u5668\u5b98\uff0f\u7d44\u7e54\u7684\u4fee\u5fa9\u3002<\/p>\n\n\n\n

\u66f4\u53b2\u5bb3\u7684\u4e00\u9ede\uff0c\u7576\u524d\u7570\u9ad4\u7d30\u80de\u6cbb\u7642\uff0c\u75c5\u4eba\u6216\u591a\u6216\u5c11\u6703\u51fa\u73fe\u514d\u75ab\u6392\u65a5\u53cd\u61c9\uff0c\u56e0\u6b64\uff0c\u5728\u6cbb\u7642\u524d\uff0c\u53ef\u80fd\u9700\u8981\u6ce8\u5165\u514d\u75ab\u6291\u5236\u5291(\u4eba\u985e\u8840\u7403\u6297\u539fHLA)\uff0c\u907f\u514d\u514d\u75ab\u6392\u65a5\u53cd\u61c9\uff0c\u800c\u7570\u9ad4\u79fb\u690d\u7684Muse\u7d30\u80de\u5247\u7121\u9700\u4eba\u985e\u8840\u7403\u6297\u539fHLA\u914d\u5c0d\u6216\u9577\u671f\u4f7f\u7528\u514d\u75ab\u6291\u5236\u5291\u3002<\/p>\n\n\n\n

\u4e09\u9762\u5411\u8457\u624b \u4fdd\u969c\u75c5\u60a3\u6b0a\u76ca<\/span><\/strong><\/p>\n\n\n\n

\u5f9e2018\u5e74\u958b\u59cb\uff0c\u65e5\u672c\u4e09\u83f1\u5316\u5b78\u63a7\u80a1\u65d7\u4e0b\u518d\u751f\u91ab\u5b78\u696d\u52d9\u7684\u751f\u547d\u79d1\u5b78\u7814\u7a76\u5c31\u5168\u529b\u52a0\u901fMuse\u7d30\u80de\u7684\u81e8\u5e8a\u61c9\u7528\uff0c\u76ee\u524d\u7814\u7a76\u767c\u73feMuse\u7d30\u80de\u6709\u671b\u6cbb\u7642\u5fc3\u808c\u6897\u585e\u3001\u8166\u4e2d\u98a8\u53ca\u7f55\u898b\u75be\u75c5\uff0c\u800c\u4e14\u6c92\u6709\u56b4\u91cd\u7684\u526f\u4f5c\u7528\u3002<\/p>\n\n\n\n

\u5e79\u7d30\u80de\u6216\u7d30\u80de\u7642\u6cd5\u662f\u91ab\u7642\u7684\u660e\u65e5\u4e4b\u661f\uff0c\u96d6\u7136\u53f0\u7063\u5df2\u7d93\u901a\u904e\u300a\u7279\u7ba1\u6cd5\u300b\uff0c\u9084\u662f\u6709\u5f88\u591a\u722d\u8b70\uff0c\u6700\u5927\u7684\u722d\u8b70\u5728\u65bc\u6cbb\u7642\u6548\u679c\u7684\u4e0d\u78ba\u5b9a\u6027\uff0c\u52a0\u4e0a\u6536\u8cbb\u6602\u8cb4\uff0c\u6bcf\u4e00\u500b\u7642\u7a0b\u53ef\u52d5\u8f12\u4e0a\u767e\u842c\u53f0\u5e63\u3002 \u5c0d\u6b64\uff0c\u6797\u677e\u6d32\u5efa\u8b70\u4e09\u65b9\u9762\u4fdd\u969c\u75c5\u60a3\u6b0a\u76ca\uff0c\u4e00\u3001\u7522\u54c1\u8981\u6709\u4fdd\u96aa\uff0c\u5728\u7d30\u80de\u6cbb\u7642\u4e2d\u7522\u751f\u4e0d\u826f\u53cd\u61c9\uff0c\u4e00\u5b9a\u8981\u6709\u88dc\u6551\u63aa\u65bd\uff1b\u4e8c\u3001\u8cc7\u8a0a\u900f\u660e\uff0c\u63ed\u9732\u53ef\u57f7\u884c\u7684\u91ab\u9662\u3001\u6cbb\u7642\u65b9\u5f0f\u3001\u53ef\u57f7\u884c\u91ab\u5e2b\u53ca\u6536\u8cbb\u65b9\u5f0f\uff1b\u4e09\u3001\u53ef\u4f9d\u6cbb\u7642\u6210\u679c\u5206\u968e\u6bb5\u6536\u8cbb\uff0c\u66f4\u4e0d\u5efa\u8b70\u5728\u6cbb\u7642\u7121\u6548\u4e4b\u5f8c\u63a1\u53d6\u7d22\u8ce0\u6216\u9000\u8cbb\u65b9\u5f0f\uff0c\u7522\u751f\u66f4\u5927\u7684\u91ab\u7642\u8a34\u8a1f\u3002<\/p>\n\n\n\n

\"\"<\/figure>\n","protected":false},"excerpt":{"rendered":"<\/p>\n

\u6587\uff0e\u8521\u6b66\u7a46<\/p>\n<\/p>\n

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\u518d\u751f\u91ab\u5b78\u662f\u5229\u7528\u7d30\u80de\u7684\u518d\u751f\u80fd\u529b\uff0c\u4fee\u88dc\u53d7\u640d\u7684\u7d44\u7e54\u3001\u5668\u5b98\uff0c\u4f7f\u6062\u5fa9\u5230\u539f\u6709\u72c0\u614b\u7684\u91ab\u7642\u6280\u8853\uff0c\u88ab \u2026\u7e7c\u7e8c\u95b1\u8b80<\/a><\/span><\/p>\n

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